DNA Analysis

SEND US YOUR SAMPLES AND RECEIVE AN ANALYSIS REPORT

01 Overview

A NEW TECHNOLOGY FOR PROFILING CIRCULATING CELL FREE DNA

Circulating Cell-free DNA (ccfDNA) is now recognized as a potential biomarker enabling personalized medicine for a wide range of pathologies

NEVERTHELESS

ccfDNA analysis is still limited by:
– Low concentration
– Complex, costly and time consuming methods – Issues of yield and reliability

BUT

Picometrics BIABooster can easily profile circulating cell-free DNA (ccfDNA) with a 100-1000x gain of sensitivity compared to the best electrophoresis technics.

For giving a FAST, EASY and AFFORDABLE access to this new technology, Picometrics has launched a new service for DNA analysis, especially for circulating cell-free DNA analysis. Send samples, receive results!

ccfDNA analysis UP TO 1000 times more sensitive than state-of-the-art electrophoresis systems

ccfDNA analysis UP TO 1000 times more sensitive

02 Profiling your samples

PROFILING CIRCULATING CELL-FREE DNA

Getting a DNA profile of plasmatic free DNA is almost impossible using existing electrophoresis systems.
But it is an easy thing with the BIABooster, an innovative plug-in for capillary electrophoresis.

“Usually, only a small amount of clinical samples is required for an informative analysis. We all know how precious clinical samples are!”

03 Getting quantified results

The BIABooster Analytics software converts raw data into meaningful information for the researcher.

The sizes of main peaks are given, as well as DNA concentration for any size range between 0.1 and 1.5 kb. Moreover, quantitative indicators are given for the presence of smaller and larger DNA.

Customers receive a comprehensive report which includes experimental reference and QC, detailed size and concentration results for each sample, as well as a summary table allowing further treatment in spreadsheet like excel™.

04 Benefits

Why analyzing circulating cell-free DNA?

A powerful Quality Control of ccfDNA :

Quantify reliably DNA concentration ;
Avoid sending to sequencing too degraded DNA
Detect high molecular weight DNA coming from leucocytes during pre-analytical steps ;

A potential generic biomarker:

Very numerous studies show an increase of ccfDNA concentration related to pathology in cancer, sepsis, inflammation, etc.
Numerous studies indicate that adding an integrity index to DNA concentration drastically increases the diagnostic/prognostic value of ccfDNA in cancer.
Potential to monitor therapeutic response, to monitor survivors during remission …

05 Our Service Offer

Simple process : Send DNA samples to Picometrics, you will receive quantified profiles in return.

Samples type :

  • ccfDNA samples : 10 μl of purified DNA containing the equivalent of ~ 100 μl of plasma or serum.
  • Other DNA samples: 10 µl of purified DNA containing at least 5 ng/ml for a complex sample, or 0.1 ng/ml for a single DNA band, in the 0.1 – 1.5 kb range.

For other size ranges, please contact us.

Contact us for a quotation

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